A Functional Leptin System Is Essential for Sodium Tungstate Antiobesity Action
نویسندگان
چکیده
منابع مشابه
A functional leptin system is essential for sodium tungstate antiobesity action.
Sodium tungstate is a novel agent in the treatment of obesity. In diet-induced obese rats, it is able to reduce body weight gain by increasing energy expenditure. This study evaluated the role of leptin, a key regulator of energy homeostasis, in the tungstate antiobesity effect. Leptin receptor-deficient Zucker fa/fa rats and leptin-deficient ob/ob mice were treated with tungstate. In lean anim...
متن کاملSodium tungstate regulates food intake and body weight through activation of the hypothalamic leptin pathway.
AIMS Sodium tungstate is an anti-obesity drug targeting peripheral tissues. In vivo, sodium tungstate reduces body weight gain and food intake through increasing energy expenditure and lipid oxidation, but it also modulates hypothalamic gene expression when orally administered, raising the possibility of a direct effect of sodium tungstate on the central nervous system. METHODS Sodium tungsta...
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The aim of this present work is to study, the corrosion behavior of carbon steel in well water in the presence of sodium tungstate (ST)-Zn 2+ -N-(phosphenomethyl) iminodiaceticacid (NPMIDA) solutions. Electrochemical studies and FTIR spectral studies and weight loss study have been employed. It was found that the inhibition efficiency (IE) of ST (50 ppm)-Zn 2+ (10 ppm) was improved from 8% to 8...
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Diabetes is a complex metabolic disorder triggered by the deficient secretion of insulin by the pancreatic β-cell or the resistance of peripheral tissues to the action of the hormone. Chronic hyperglycemia is the major consequence of this failure, and also the main cause of diabetic problems. Indeed, several clinical trials have agreed in that tight glycemic control is the best way to stop prog...
متن کاملRole of sodium tungstate as a potential antiplatelet agent
PURPOSE Platelet inhibition is a key strategy in the management of atherothrombosis. However, the large variability in response to current strategies leads to the search for alternative inhibitors. The antiplatelet effect of the inorganic salt sodium tungstate (Na2O4W), a protein tyrosine phosphatase 1B (PTP1B) inhibitor, has been investigated in this study. METHODS Wild-type (WT) and PTP1B k...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2009
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2008-0881